【摘要】 确立药物静注、恒速静滴、肌注改口服后的首剂口服药物时间,其给予时间应以静注、静滴后的初始浓度、肌注后的达峰浓度降至拟定的最低有效浓度所需的时间“T”为基点,在“T”具体时间量上,提前该药1/8达峰时间给药的观点。即“T-1/8tm”给药方法,且论述了“T-1/8tm”、“T-1/6tm”、“T-1/10tm”三种给药法的可行性。发现了在“T-1/8tm”等给药后,静注及多种不同速率静滴及肌注的药-时曲线的相同性。并界定了“T-1/8tm”给药法的必备条件和适用范围。更多还原

【Abstract】 The time of first oral dose given after the alternation of ⅳ, drip and im to oral method was established. Time given should be based upon the initail concentration after ⅳ and drip and the time (T)required from the maximum concentration after im decreasing to the lowest effective concenttration. This method was called T—1/8 drug giving method.We also discussed and evaluated the feasibility of three kinds of drug-giving methods T—1/8tm, T—1/6tm and T—1/10tm We found that in the method of T—1/8tm, the time curve of ⅳ, drip and im was identical. We established the conditions required and the scope of application of T—1/8tm method.更多还原