【摘要】 本文用家兔就苯妥因钠、丙戊酸钠及安定对卡马西平药代动力学的影响进行了实验研究。采用高效液相色谱法测定卡马西平血清浓度,结果表明,服用苯妥因后,卡马西平代谢明显加快,消除速率常数K由0.326h—1升高到0.528h—1;半衰期T_1/2由2.14h减少到1.33h;清除率CL由1.81L/kg·h升高到7.74L/kg·h,经t检验,均有显著性差异（P<0.05）,口服丙戊酸钠后,卡马西平的药动学参数K及T_1/2无显著变化（P>0.05）。但CL由1.40L/h·kg升高到2.04L/h·kg。表现分布容积Vd由5.08L/kg增加到8.37L/kg,经t检验,有显著性差异（P<0.05）。服用安定后,卡马西平药动学参数K由0.305h—1减少到0.187h—1,CL由2.19L/kg·h降低到1.38L/kg·h。经t检验,有显著性差异（P<0.05）,而T_1/2及Vd无显著性差异（P>0.05）。更多还原

【Abstract】 This paper deals with the effects of Phcnytoin (PHT), Valproic acid (VPA), Diazepam on pharmacokinetic to Carbamazcpin (CBZ) in rabbits. The concentrations of CBZ in serum were determined by high-performance liquid chromatography. The results indicated that after the oral administration of PHT , CBZ was metabolized faster than before. The elimination rate consant (K ) increased from 0. 326h-1 to 0.528h-1, the elimination half-lift (t0.5) decreased from 2. 14h to 1. 33h, and the clearance (CD increased from 1. 18L/kg. h to 7. 74L/kg. h. There were significant differences (t test, P <0. 05). After the oral administration of VPA, the pharmacokinetic parameters K and t0.5 of CBZ have no significant difference (t test, P<0. 05), but CL increased from 1. 40L/h. kg to 2. 04L/h. kg , and the apparent volume of distribution (Vd) increased from 5. 08L/kg to 8. 37L/kg. There were significant differences (t test, P<0. 05). After the oral administration of diazepam, the pharmacokinetic parameters K of CBZ decreased from 0.305 h-1 to 0. 187h-1 and CL from 2. 19L/kg. hr to 1. 38L/kg. h, respectively. There were significant differences (t test, P<0.05), but t0.5 and Vd have no significant difference (t test, P<0.05).更多还原