【摘要】 采用小鼠自然戒断和催促实验评价丙氧氨酚的身体依赖性潜力。丙氧氨酚ｉｇ３００—６００ｍｇ·ｋｇ－１·ｄ－１连续３０ｄ，或ｉｇ总量为３．２７ｇ·ｋｇ－１的丙氧氨酚，ｉｐ环丙羟丙吗啡（Ｍ５０５０）３ｍｇ·ｋｇ－１催促，体重明显下降。丙氧氨酚２．０－３．０ｇ·ｋｇ－１·ｄ－１连续ｉｇ６ｄ后，ｉｐＭ５０５０３ｍｇ·ｋｇ－１催促，大鼠体重明显下降并出现了与吗啡相似的戒断症状。当大鼠吗啡掺食５ｄ产生身体依赖之后，用丙氧氨酚０８－１．６ｇ·ｋｇ－１·ｄ－１ｉｇ替代，可减轻其戒断后的体重下降。恒河猴丙氧氨酚６０－９０ｍｇ·ｋｇ－１·ｄ－１８ｗｋ后，ｓｃＭ５０５０１ｍｇ·ｋｇ－１催促或ｉｇ６０－９０ｍｇ·ｋｇ－１·ｄ－１１１ｗｋ后断然停药，恒河猴出现明显戒断症状。上述实验说明丙氧氨酚具有一定的身体依赖性潜力。更多还原

【Abstract】 The potential of physical dependence of propoxyacetamolum wasstudied. The results showed that mild or moderate withdrawal syndromes occured whenmice, rats and rhesus monkeys were occured in abrupt withdrawal of propoxyacetamolumand challenged with diprenorphine. In physical dependent rats, propoxyacetamolum(ig, 0. 8 -- 1. 6 g. kg-1) could partially inhibit body weight lose induced by morphine withdrawal. It is concluded that the withdrawal signs in propoxyacetamolumdependent animals are similar to that of morphine or codeine, but the potential ofphysical dependence of propoxyacetamolum is significantly lower than that of morphine. In comparison of propoxyacetamolum with its active ingredients propoxypheneand paracetamol, propoxyphene is responsible for the dependent properties ofpropoxyacetamolum.更多还原