【摘要】 本文以手性α-异丙基对氯苄胺为手性诱导试剂和取代苯甲醛生成的席夫碱与亚磷酸酯进行不对称加成反应,生成具有双手性中心的N-取代-α-氨基膦酸酯。化学产率为40～91％,de％可达到72％。并简单讨论了立体效应对光学诱导能力的影响。更多还原

【Abstract】 Chiral N - substituted - α - aminophosphonates were synthesized stereoselectively by addition of dialkylphosphites and chiral imines, using ( S ) - α - iso - propylbenzylamine as chiral inducing agent. The de was up to 72 % and yields were 30 - 90 % . The stereoeffects on the optical and chemical yields were discussed briefly.更多还原