【摘要】 应用PCR扩增产物直接对3名氨基糖甙类抗生素致聋患者的线粒体DNA进行序列分析，结果表明，他们的线粒体DNA均存在第1555位核苷酸A－G的突变．因此认为该突变是人体对氨基精甙类抗生素致聋遗传易感性的分子基础，与氨基糖甙类抗生素共同作用造成耳聋。更多还原

【Abstract】 The mitochondria DNAs (mtDNAs) of thrce patients with AAID were analysed using the method of direct sequeneing of their PCR produets. The results showed that all their mtDNAs had an A-G mutation at nucleotides 1 555. It is considered that this mutation is the molecular basis causing human susceptibility to Aminoglycoside Antibiotics toxicity which in coopcration with Aminoglycoside Antibiotics results in deafness.更多还原