【摘要】 目的：实验观察油酸型急性肺水肿家兔血浆纤维连接蛋白（Ｆｎ）和肺表面活性物质（ＰＳ）含量的变化，以及给予山莨菪碱（６５４－２）后对其变化的影响。方法：家兔４０只分４组。采用静脉注射油酸０．１２ｍｌ·ｋｇ－１复制油酸型肺水肿模型，预防组和治疗组在注油酸前、后分别给予６５４－２１０ｍｇ·ｋｇ－１，ｉｖ。其它组给予生理盐水对照。结果：肺水肿组血浆Ｆｎ含量明显减少，肺组织匀浆ＰＳ含量亦明显减少。肺损伤前给予６５４－２，可阻止血浆Ｆｎ及ＰＳ的减少。结论：血浆Ｆｎ含量不足使肺毛细血管膜受损，血管通透性增高，引发或加重了肺水肿，６５４－２能阻止这一过程，从而减轻肺水肿的发生发展。更多还原

【Abstract】 To research the change of plasma fibronectin (Fn) and pulmonary surfactant (PS) and the effect of 654 2 on the content of Fn and PS in rabbits with pulmonary edema caused by oleic acid. Forty rabbits were divided into control group (received physiological saline), pulmonary edema group (injected oleic acid by vein with 0 12 mg·kg -1 ), preventive group (administrated 654 2 by vein with 10 mg·kg -1 before injecting oleic acid) and treatment group (received 654 2 by vein after injecting oleic acid). The contents of Fn and PS decreased markedly ( P <0 01) in pulmonary edema group. The decrease of Fn and PS can be prevented by injecting 654 2 by vein before giving oleic acid. Insufficiency of Fn may be responsible for the damage of pulmonary capillary, the increase of capillary permeability, and the aggravation and inducement of pulmonary edema. 654 2 can prevent the situation from developing and attacking.更多还原