【摘要】 目的探讨肝脏冷保存与移植肝原发性无功能的关系。方法采用具有免疫耐受性的同种大鼠原位肝移植模型进行研究。将鼠肝分别在４℃ＵＷ液中保存１，６和２４ｈ，分别在移植后１ｈ和２４ｈ取肝脏做病理观察。结果保存在ＵＷ液中的肝脏基本保存了正常的组织结构，而在移植后则不同程度地出现了变性或坏死，并且肝细胞的坏死以小叶中央静脉为中心。保存时间越长，病变越严重。结论肝脏冷保存时间与移植肝原发性无功能的发生密切相关。更多还原

【Abstract】 AIMS\ To investigate the relation between cold preservation of liver and primary nonfunction of transplanted liver. METHODS\ We proceeded study with the model of allogenic orthotopic transplantation of liver in rats that have immunologic tolerance. Rat livers were put in UW solution at 4℃ for 1, 6 and 24 hours, and then transplanted, respectively. The samples were taken for pathology at the first and twenty fourth hour after transplantation. RESULTS\ Normal structure was kept in livers preserved in UW solution, while degeneration or necrosis were observed in the transplanted livers, and the necroses were around the central vein. The longer the preserving time, the more severe the pathologic change. CONCLUSIONS\ There is a relation between the time of cold preservation of liver and the development of primary nonfunction of transplanted liver.更多还原