【摘要】 应用放射免疫测定研究了大白鼠经腹腔注射、灌胃和尾静脉注射小剂量ＳｍＣｌ_３，０．０５ｍｇ／ｋｇ后，血清中甲状腺激素（Ｔ_３、Ｔ_４）和促甲状腺激素（ＴＳＨ）浓度的变化；并在电镜下观察了甲状腺和腺垂体促甲状腺激素细胞的超微结构。结果显示：经腹腔注射小剂量ＳｍＣｌ_３后，大鼠血清中Ｔ_４浓度增高，ＴＳＨ浓度无显著变化；经灌胃和尾静脉注射等量的ＳｍＣｌ_３后，大鼠血清中Ｔ_３、Ｔ_４和ＴＳＨ浓度均无明显变化。在电镜下，甲状腺滤泡上皮细胞和腺垂体中的促甲状腺激素细胞的超微结构听见均与其血清中所测激素浓度变化意义相同。更多还原

【Abstract】 he levels of thyroxine(T3, T4 ) and thyroid stimulating hormone (TSH) in rat serum were measured by radioimmunoassay , and also ultrastructures of the thyroid gland and adenohypophyseal thyrotroph were examined by transmission electronic microscope (TEM), after the rats were given low concentration(0. 05 mg/kg) of samarium chloride by the intraperitoneal, oral and tail intravenous. The results showed that the level of T4 in the rat serum increased and the level of TSH unchanged abviously by the intraperitoneal, and the levels of T3, T4 and TSH were not increased significantly by oral and tail intravenous. The evidences mentioned above were accord with the morphological changes of thyroid follicular epithelial cell and adenohypophysis thyrotroph seen under electronic microscopy in a sense.更多还原