【摘要】 本文就近十年来我们在67例特重烧伤病人治疗过程中血液凝固系统变化及DIC的发生诊治方面进行了初步分析及总结。体会到:(1)对大面积烧伤病人的处理中要高度警惕DIC的发生,防患于未然。(2)休克、败血症与DIC及多脏器功能衰竭互为因果。(3)抗休克、抗感染及烧伤原发病的治疗以及烧伤后即开始应用小剂量肝素(10mg/日皮下注射)是预防DIC发生的关键环节,一旦DIC诊断成立后,根据凝血系统异常及三P试验阳性的表规,积极采取抗凝、抗纤溶药及凝血物质的应用,防止DIC的继续发展。更多还原

【Abstract】 The article based on the analysis of the hemocoagulation system in 67 adult patients who were admitted to our hospital after sustaining bum injuries initially greater than 70% body surface area. Coagulation studies(Prothrombin time,Platelet count, Fibrinogen) were done in these patients. Results were abnormal in 54 of the total number in shock period,and then, the abnormalities get over after shock period gradually. Conclusive evidence of disseminated intravascular coagulation (DIC) was found in 10 patients, three patients died. It was concluded that DIC in patients with burn injuries greater than 70% body surface area occurs more often(the incidence of DIC is 14.93% in this report) than other trauma and head injury(the incidence of DIC rages from 3 % to 13 % ). To diagnose DIC with burn injury, we may do 4 laboratory(PT, BPC, fibrinnogen and 3P test) and find abnormalities in at least 3 of 4 laboratory values,besides with clinical signs. DIC following burn injury must first be treated by specific therapy of burn injury,antiinfection and general support measures. Low doses heparin anticoagulation and anti - platelet drug followed by aggressive replacement with platelets, and fresh plasma.更多还原