【摘要】 观察了81例不同肝病患者7项血液抗凝和纤溶指标的变化,并以传统的白蛋白和凝血酶原时间(PT)测定为对照,比较了各项指标在肝病诊断中的敏感性。结果发现肝病患者的抗凝和纤溶功能有明显改变,敏感性较高的指标为抗凝血酶Ⅲ活性(ATⅢ:A)、纤溶酶原活性(Pg:A)和纤溶酶原激活物抑制物活性(PAI:A)分别为75.3％、69.1％和71.6％,均明显高于白蛋白(44.4％)和PT(40.7％)。分析肝病出血与各项指标的关系,发现ATⅢ:A和Pg:A降低,组织型纤溶酶原激活物活性(t—PA:A)升高在出血者显著高于非出血者。更多还原

【Abstract】 Seven Parameters of anticoaguJation and fibrinolysis were investigated in 81 patients with various liver diseases and compared with traditional determination of albimin and pro-thrombin time for their diagnostic sensitivities. The results revealed prominent changes in both anticoagulation and fibrinolysis in patients with liver diseases. Among the seven parameters investigated antithrombin Ⅲ activity (AT Ⅲ : A), plasminogen activity (Pg: A) and plasminogen activator inhibitor activity (PAI:A) were the most sensitive ones. The sensitivities of AT DI : A (75.3%), Pg : A (69. 1%) and PAI : A (71. 6%) were significantly higher than albumin (44.4 % ) and PT (40.7%). Analysis of the relation between hemorrhage risk and changes in the parameters found that AT Ⅲ : A and Pg: A were greatly decreased and t-PA: A elevated in patients with bleeding complications as compared to the non-hemorrhagic patients.更多还原