【摘要】 本文报道了42例低体重儿应用全静脉管养中，发生胆汁瘀积（TPN－AC）6例（14％），认为TPN—AC发生后尽早改为部分静脉管养（PPN）或停用TPN，以减少热卡摄入和脂肪，氨基酸对肝脏的继续损害，是治疗成功的关键。同时给予利胆等对症处理，可促进胆汁的分泌和排泄。在治疗中，均未使用皮质激素。病情改善令人满意，文章指出在应用TPN时，应注意监测肝、肾功能，积极防治TPN－AC的发生和发展，TPN时间应控制在2—4周以内。更多还原

【Abstract】 6 cases of total parenteral Nutrition-associated cholestasis (TPN-AC) amony 43 cas es of low weight infants received total parcnteral Nutrition (TPN) were reported. We found that it was essential to stop TPN or change over to partial parenteral nutrition as long as the onset of TPN-AC in order to reduce high caloric intake and prevent the liver from further damage by fat and amino-acid. At the same time. Cholecystagogue was given to promote the secretion and discharge of the bile. cortisone has not been used. The patients’ condition were improved significautly. It was concluded that the liver and renal functions should be monitored carefully and the onset of TPN-AC prevented during using TPN. The duration of TPN shonld be controlled in 2-4 weeks更多还原