【摘要】 测定43例行大肠癌根治术的大肠癌病人的空腹血清、癌组织、癌旁粘膜中胃泌素水平。结果大肠癌病人空腹血清胃泌素水平明显高于对照组(P<0.05);根治术后明显降低(P<0.05),且与对照组相比无显著差异(P>0.05)。高分化腺癌及DukesA期大肠癌组织血清胃泌素水平变化明显。大肠癌组织及癌旁粘膜中胃泌素水平均高于正常大肠粘膜(P<0.05)。表明胃泌素对大肠癌的生长有调控作用,测定血清及癌组织中胃泌素水平有助于对大肠癌的诊断及指导激素治疗。更多还原

【Abstract】 Gastrin(G) concentrations in fasting sera, cancer tissues and adjacent - cancer mu-cosas of 43 patients with large intestine carcinoma (LIC) were measured. The results showed that G le -vels in fasting patients with LIC was significantly higher than that of the normal controls (P<0. 05) and decreased to normal value after the radical resection of cancers. No significant changes of alevel were observed in the patients with differentiation adenocarcinoma and LIC in Dukes stage A, The cancer tissues and its adjacent mucosas contained higher levels of G than the normal mucosas (P<0. 05). The results provided a laboratory evidence that the growth of LIC in vivo were regulated by G and G level might be an indicative parametes for the diagnosis of LIC.更多还原