【摘要】 本文目的在于了解抗中性粒细胞胞浆抗体(ANCA)在国内溃疡性结肠炎(UC)病人中的阳性率和对UC的诊断意义,及其与病理之间的关系。应用间接免疫荧光法检测ANCA,32例UC病人中9例阳性,阳性率28.1％,全部呈核周型(pANCA);15例肠易激综合征、4例克隆病、10例其他原因引起腹泻的病人,以及49例健康对照全部阴性。组织病理学检查发现,ANCA阳性者粘膜血管炎发生率为88.9％(8/9),ANCA阴性者为44.4％(8/18),结果显示:ANCA对鉴别UC与其他腹泻性疾病有意义;ANCA可能通过介导肠粘膜血管炎参与UC的发病。更多还原

【Abstract】 Aims: To evaluate the diagnostic value and pathogenic role of antineutrophil cytoplasmic antibody in ulcerative colitis (UC). Methods: Antineutrophil cytoplasmic antibody (ANCA) was detected by indirect immunofluorescence. Pathologic changes of colonic mucosal biopsies were studied. Results: 9/32 UC patients (28.1%) were pANCA positive, 29 disease control patients and 49 health control subjects were all ANCA negative. The sensitivity and specificity of ANCA for UC was 28.1% and 100%, respectively. Pathologic study showed that ANCA positive patients had a higher prevalence of mucosal vasculitis (88.9% vs 44.4%, P<0.05) and higher degree (Ⅲ - Ⅴ grades) of mucosal inflammation (77.8% vs 33.3%, P<0.05) than ANCA negative patients. Conclusion: ANCA is a specific clinical test for differential diagnosis of UC in diarrheic patients. ANCA may participate in the pathogenesis of UC by inducing mucosal vasculitis.更多还原