【摘要】 用人体胎盘型ＧＳＴ－π抗体，按ＡＢＣ免疫组织化学技术，检测了５０例食管癌、６８例癌旁组织和５１例正常对照组。并对其中３０例食管癌和２０例正常组进行了组织和血清ＧＳＴ活性检测。结果表明：正常食管组织ＧＳＴ－π阳性率为３．９２％，不典型增生组为７７．９４％，食管癌组为８６％。３０例食管癌组织和血清ＧＳＴ活性均值分别为：２．３９３±１．２１８和１６．６２０±４．４５０，而２０例正常组织和血清ＧＳＴ均值分别为：１．０６４±０．４９４和１３．４４０±４．００４，两组间差异显著（Ｐ＜０．０１）。ＧＳＴ－π在食管癌患者的表达为研究其发病机理和早期诊断提供了新的酶学指标。更多还原

【Abstract】 In this study,50 esonhageel carcinoma(EC),68 dysplasia and 51 normaI tissue of esophagus with methods of immunohistochemical stains (ABC)of placental form of glutothione(GST-π).The contents in tissue and serum of GST were determind for 30 EC and 20 tissue of normal esophagus. The result indicated:the postive rates of GST-π in EC and dysplasia groups were 86% and 77.9% respectively.The positive rates of GST-π in tissue of normal esophagus was 3.92%. The activity of GST in the tissue and serum of 30 patients with EC were 2.393±1.218 and 16.620±4.540 respectively. The activity of GST in the tissue and serum of 20 normal subject were 1.064±0.494 and 13.440±4. 004. the differate was very significant(P<0. 01). The result demonstrated that GST-π is an new maker of immunohistochemistry of EC precancerous lession.It is important to study the pathogenesis and early diagnosis.更多还原