【摘要】 为了探讨乙醇对动物卵巢功能的影响，本实验采用放射免疫测定法及阴道脱落细胞涂片法，对灌服乙醇前后雌性大鼠血清中的雌二醇（Ｅ２）与孕酮（Ｐ）水平及动情周期进行了观察。结果显示，实验后大鼠的Ｅ２明显低于其实验前水平（Ｐ＜０．００１），Ｐ也有不同程度的变化。在实验过程中，除一只大鼠的动情周期停滞于间情期不再发生变化外，另有３只大鼠的动情周期显著延长为７天。提示较大剂量的乙醇可导致正常大鼠的卵巢功能紊乱。更多还原

【Abstract】 Objective: To observe the effect of ethanol on ovarian function in rats. Methods: Twenty four female Wister rats in normal estrous cycles were given 20% ethanol aqueos solution by intra gastric perfusion (5ml/day per rat) for 12 days. The serum concentrations of E 2 and P were measured by radioimmunoassay and the estrous cycles changes were detected by vaginal exfotiative cytologic examination before and after experiments. Results:The serum concentrations of E 2 in the rats in various stages were extensively decreased compared with that before the experiments. The concentrations of P also had certain significant changes. The estrous cycles were prolonged remarkably in some rats and even stopped in anestrum in one rat during the ethanol treament. Conclusion: The result suggested that ethanol may severely interfuse the ovarian function in female rats with abnormal endocrine of E 2 and P and disturbance of estrous cycles.更多还原