【摘要】 本文采用发色底物法及放免法检测了４７例老年及老年前期原发性高血压病（ＥＨ）患者和２５例健康老年人血浆组织型纤溶酶原激活物（ｔ－ＰＡ）、纤溶酶原激活的抑制因子（ＰＡＩ）、空腹血浆胰岛素（Ｉｎ）及血糖水平（Ｇ），分析了胰岛素敏感性（ＩＳ）与纤溶活性、体重指数（ＢＭＩ）、血压（ＢＰ）的相关性。结果显示：ＥＨ患者血浆ＰＡＩ活性明显高于对照组，血浆ｔ－ＰＡ活性、ＩＳ明显低于对照组；ＩＳ与ＢＭＩ、ＰＡＩ、ＢＰ呈显著负相关，与ｔ－ＰＡ呈显著正相关。提示纤溶活性异常与胰岛素抵抗共同在高血压病的发生发展中起重要作用。更多还原

【Abstract】 We measured the plasma tissuetype plasminogen activator(t PA) activity, plasminogen activator inhibitor(PAI) activity, fasting plasma insulin and glucose levels in 56 aged patients with essential hypertension (EH) and 30 control subjects. It was found that PAI activity was significantly higher and t PA activity and IS(insulin sensitivity)were significantly lower in EH group than in cotrol subjects. By univariable analyses,it was found that insulin sensitivity was negatively correlated with BMI(body mass index), and the PAI activity and BP(blood pressure) were positively correlated with t PA activity in EH group.更多还原