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抗M血型抗原单克隆抗体特性的研究
Study on Characteristics of McAb to M Blood-group Antigen
【摘要】 以OM型人红细胞膜血型糖蛋白A为抗原,通过交瘤技术,获得一株稳定分泌抗M血型抗原的单抗细胞株(4E6)。所分泌抗体类型为IgG2b。4E6能特异性识别M型血型糖蛋白A的双聚体及单体;4E6与M型PanelA红细胞呈持异性反应;临床初步应用表明,4E6可用于对M、N血型系统的分型。
【Abstract】 A cell strain (4E6) which could stably secrete McAbs (IgG2b) to M blood group antigen was obtained by hybridoma technique using OM group erythrocyte membrane blood-group glucoprotein A as antigen. The strain could specifically recognize the dimer and monomer of M group glucoprotein A and react with M group Panel A red cells. Preliminary clinical application indicated that 4E6 could be used for M, N blood-group typing system.
- 【文献出处】 中国生物制品学杂志 ,Chinese Journal of Biologicals , 编辑部邮箱 ,1996年02期
- 【分类号】R392
- 【被引频次】8
- 【下载频次】39