【摘要】 采用体外热应激的方法观察了ＨＳＰｓ对培养大鼠ＡＭ的保护作用。结果ＨＳＰｓ水平增加可保护ＡＭ抵抗石英尘毒作用，表现在ＡＭ细胞存活率明显提高，而ＭＤＡ含量及培养上清液ＬＤＨ活性明显下降。提高ＡＭＨＳＰｓ水平，可能为保护和促进肺清除功能，预防矽肺等肺部疾病的发生发展提供一条新的途径更多还原

【Abstract】 Previous studies both in vitro and in vivo demonstrated that quartz could increases the expression of HSP-70 in pulmonary macrophage and the increased level of HSPs may serve as an autoprotective mechanism. In this research, the protective effect of HSPs induced by heat stress(42℃,15 min)on the cultural AM of rats against quartz were studied. The results showed that the increased level of HSPs in AM could obviously increase the survival rate of AM and remarkedly decrease the content of MDA of AM and the LDH activity of the culture medium. It was suggested that raising the level of HSPs in AM may provide a new route for protecting and improving lung clearance mechanism, preventing the development and progression of silicosis and other lung diseases.更多还原