【摘要】 本工作目的是在离体大鼠肠系膜动脉床灌流模型上，观察几种常见炎症介质：前列腺素Ｅ２（ＰＧＥ２）、缓激肽（ＢＫ）、组胺（ＨＩＳ）、血小板活化因子（ＰＡＦ）及５－羟色胺（５－ＨＴ）对血管周围感觉神经介质ＣＧＲＰ释放的直接影响。结果显示：ＰＧＥ２（１－１００μｍｏｌ／Ｌ）和ＢＫ（５－１０μｍｏｌ／Ｌ）能引起大鼠肠系膜动脉床时间和浓度依赖性地释放ＣＧＲＰ。ＨＩＳ，ＰＡＦ和５－ＨＴ则未见明显作用。结果提示，ＰＧＥ２与ＢＫ可能是引起血管周围感觉神经兴奋和ＣＧＲＰ释放的主要炎症介质。更多还原

【Abstract】 The purpose of the present study was to observe whether inflammatory mediators,such as: Prostaglandin E2 (PGE2), Bradykinin (BK), Histamine (HIS), Platelet activefactor (PAF) and 5-hydroxytryptamine (5-HT), directly triggered the release ofCGRP from perivascular nerves in isolated rat mesenteric arterial bed. The resultsshowed that PGE2 (1-100 umol/L) and BK (5-10 umol/L) caused time- and conceniration-dependent CGRP release, but HIS, PAF and 5-HT did not show significant effeets. Our data indicate that PGE2 and BK are the major inflammatory mediators in triggering the release of CGRP from the perivascular CGRP-containing nerve.更多还原