【摘要】 健康ＳＤ雄性大鼠，体重２５０—３００ｇ，麻醉、气管插管，用人工呼吸机经气袋供气，自发吸入氧浓度为９％的氧氮混合气，用高效液相色谱－电化学联合检测法及电阻法检测循环血液中儿茶酚胺及全血血小板聚集性的动态变化。结果：急性低氧１５ｍｉｎ时血液中肾上腺素（Ａ）浓度及全血血小板聚集性显著增加（Ｐ＜０．０１），而去甲肾上腺素（ＮＡ）浓度虽有所增加，但无统计学意义（Ｐ＞０．０５）；复氧１５ｍｉｎ时血液中儿茶酚胺浓度及全血血小板聚集性皆恢复至正常水平；摘除双侧肾上腺后即刻低氧１５ｍｉｎ时血液中ＮＡ浓度无统计学改变（Ｐ＞０．０５），而Ａ浓度及全血血小板聚集性显著降低（Ｐ＜０．００１或Ｐ＜０．０５）；当摘除双侧肾上腺后３０ｍｉｎ再低氧１５ｍｉｎ时血液中的Ａ，ＮＡ浓度几乎检测不到，同时全血血小板聚集性更明显下降（Ｐ＜０．０１）；在体外血液中加入肾上腺素（１ｎｇ／ｍｌ）可以引起全血血小板聚集性显著增加。上述结果表明，急性低氧可致全血血小板聚集性增加及双侧肾上腺释放肾上腺素增加，而全血血小板聚集性的增加，可能部分是通过血液中肾上腺素浓度增加而实现的。更多还原

【Abstract】 Experiments were performed on 250-300 g male Sprague-Dawley rats underurethane (700 mg/kg) and a-chloralose (35 mg/kg) anesthesia. Plasma catecholamineconcentration and the whole blood platelet aggregation were measured during normoxia, acute hypoxia, reoxygenation, acute hypoxia immediately after bilateral adrenalectomy and acute hypoxia at the end of 15 and 30 min after bilateral adrenalectomy. Theplasma adrenaline concentration and the whole blood platelet aggregation increasedmarkedly (P<0. 01 ), while the plasma noradrenaline concentration tended to increase(P>0. 05) during acute hypoxia. The plasma adrenaline concentration and the wholeblood platelet aggregation are capable of restoring to the normal level during reoxygenanon. The plasma noradrenaline concentration did not change, while the plasma adrenaline concentration and the whole blood platelet aggregation decreased significantly(P< 0. 001 or 0. 05) during acute hypoxia for 15 min immediately after bilateral adrenalectomy. On the other hand, plasma adrenaline and noradrenaline were not detectable during acute hypoxia 30 min after bilateral adrenalectomy while the wholeblood platelet aggregation deceased markedly (P< 0. 01 ). When adrenaline (1 ng/ml) was added to the blood (in vitro), the whole blood platelet aggregstion increased significantly (P<0. 01 ). All the above results indicate that acute hypoxia leads to increament of whole blood platelet aggregation and plasma adrenaline concentration due to release from the adrenal gland and the increament of the whole blood platelet aggregationmay be partly mediated by increased plasma adrenaline.更多还原