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脑桥呼吸调整中枢向延髓Botzinger复合体轴突投射的研究

PROJECTIONS FROM PONTINE PNEUMOTAXIC CENTER TO MEDULLARY BOTZINGER COMPLEX IN CATS

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【作者】 宋刚于萍刘磊

【Author】 SONG GANG; YU PING; AND LIU LEI(Department of Physiology,Shandong Medical University,Jinan 250012)

【机构】 山东医科大学生理学教研室

【摘要】 实验在33只成年猫上进行。Botzinger复合体内微量注入麦角辣根过氧化酶(WGA-HRP,30-60nl,5%,9例)后,在脑桥呼吸调整中枢结合臂外侧核及Kolliker-Fuse核观察到大量HRP标记神经元。在20例动物中,检测了91个在呼吸调整中枢记录到的呼吸神经元对电刺激Botzinger复合体的反应。其中13个神经元(吸气性11个,跨时相2个)可被逆行兴奋。实验结果表明,发自脑桥呼吸调整中枢神经元的轴突可投射到Botzinger复合体,这一投射通路可能与呼吸调节有关。

【Abstract】 Experiments were done on 33 adult cats. After injection of WGA-HRP (5%, 30- 60 nl ) into the Botzinger complex, labeled cells were observed in the lateralparabrachial nucleus and the Kolliker-Fuse nucleus. Injection into control sites failed tolabel the cells in the above two nuclei. Ninety-one respiratory related neurons recordedfrom the pneumotuxic center were tested by electrical stimulation of the Botzinger complex. Thirteen neurons (14. 3%, inspiratory 11, phase- sawnning 2 ) could be antidromically activated. Results of the present study showed that neurons in the pneumotoxic center sent axons to the Botzinger complex concerning respiratory control.

【基金】 国家教委基础研究基金
  • 【文献出处】 生理学报 ,ACTA PHYSIOLOGICA SINICA , 编辑部邮箱 ,1996年01期
  • 【分类号】R338
  • 【被引频次】1
  • 【下载频次】30
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