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脂质体肝素透皮吸收的初步观察
Preliminary Observation on Percutaneous Absorption of Liposomal Heparin
【摘要】 以脂质体肝素5 000 u、10 000 u喷雾于12名健康自愿者皮肤上,给药后30 min、90min,凝血酶凝固时间(TCT)比给药前延长,统计学处理有显著差异(P<0.01~0.001),同时,12例中5例诉性功能增强。结果表明,本试验所用的脂质体肝素,通过开放式给药,可以穿透皮肤,进入血循环,产生抗凝效果。
【Abstract】 Liposomal heparin of 5 000 u and 10 000 u was sprayed onto the skin of 12 healthy subjects. Thrombin clotting time prolonged markedly 30-90 min after heparin application. In comparison to before spraying liposomal heparin, the difference was significant statistically (P<C0. 01 -0. 001). Furthermore, inceased sexual activity occurred in 5 out of 12 subjects. The results showed that liposomal heparin used, through open application can penetrate into human skin and blood circulation, and cause anticoagulant action.
- 【文献出处】 中国生化药物杂志 ,Chinese Journal of Biochemical Pharmaceutics , 编辑部邮箱 ,1996年01期
- 【分类号】R94
- 【被引频次】13
- 【下载频次】64