【摘要】 尿激酶型纤溶酶原激活物受体作为胞外纤溶酶系统的一员，以糖基磷脂酰肌醇锚的形式固定于细胞膜上，它参与了胞外纤溶酶活性的调节，具有内化受抑制的尿激酶的功能；同时参与了胞外信号的传递；另外它对癌症的临床预后及抗癌转移的研究有重要的意义．更多还原

【Abstract】 In the extracellular plasmin system,the receptor for a urokinase plasminogen activator (uPAR) acts as an anchorage site for uPA on the cell surface where it modulates the activities of the extracellular plasmin system, has a function of internalizing uPA-inhibitors and other complexes, transmits the extracellular signals into cells and represents a new prognostic parameter and a promising approach for anti-invasive therapy in cancer.更多还原