【摘要】 视黄酸对基因表达的调控与肿瘤细胞的分化、胚胎的发育以及疾病的发生关系密切．视黄酸的基因调控作用是通过视黄酸信号传递系统实现的．视黄酸信号传递系统包括视黄酸、细胞液视黄醇（酸）结合蛋白、视黄酸细胞核受体及视黄酸反应元件等．视黄酸信号传递系统自成一体系，在这一系列调控的级联反应中存在着多级反馈调控环节，而且该系统还与视黄酸配体以外的信号系统相联系．更多还原

【Abstract】 Retinoid signaling system is composed of retinoic acids, retinol binding proteins (RBPs ), cellular retinol binding proteins (CRBPs), cellular retinoic acid binding proteins (CRABPs), retinoic acid nuclear receptors and retinoic acid responsible elements. This system has been proved to regulate expression of many functionillg genes, such as genes of CRABP- I,c-Fos, growth factor receptor, protein kinase C,etc. Therefore, the retinoid’s role in morphogenesis during embryonic development and regulating the growth and differentiation of a wide varity of cell types throughout life of organism are involved in this signaling system.更多还原