【摘要】 降钙素和降钙素基因相关肽（ＣＴ／ＣＧＲＰ）由同一基因编码，该基因结构及其５＇端侧翼序列决定了它能够在甲状腺Ｃ细胞以及中枢和外周神经细胞生成不同的表达产物．这种选择表达调控决定多细胞生物的发育、性别分化和进化．如果表达失控将导致甲状腺髓样癌（ＭＴＣ）和骨质疏松症等疾病．文章对该基因的结构和选择性表达调控进行了综述．更多还原

【Abstract】 Calcitonin and calcitonin gene related peptide (CT/CGRP) are coded by a commensal gene, of which the structure and 5’ flanking sequence make the differential expressive products from thyroid C cell or nerve cell. The regulation of alternative expression determines the growth, sexual differentiation and evolution in multicellular animals. The medullary thyroid carcinoma (MTC) or osteoporosis would arise supposing that the abnormal expressive regulation occurs.更多还原