【摘要】 在体外用Ｃｕ^２＋诱导法使ＬＤＬ氧化修饰，利用紫外法监测氧化过程中所形成的结合二烯键，发现整个反应分为３个时相，即延迟期、快速反应期和分解期。利用硫代巴比妥反应物测定，发现氧化后ＬＤＬ中每ｍｇ蛋白脂质过氧化物增加了１５倍。更多还原

【Abstract】 Low density lipoprotein（LDL）was oxidized with Cu￣（2+）in vitro.A lag phase was followed by oxidave modification after addition of CuCl₂, and about 15 h,the reaction reach a peak. LDL oxidation was continuously monitored spectrophotometrically at 234 nm to follow the formation of conjugated dienes.Three phases were found in oxidation curve:Lag phase, propagation phase and decomposition phase. By determinating thiobarbituric acid reaction substances（TBARS）,we found the lipid peroxidation increased as much as 15 times in LDL.更多还原