【摘要】 为了在湖沼型血吸虫病重度流行区观察青蒿琥酯预防日本血吸虫感染的效果和优化服药方案,1996年4～11月,选择安徽省贵池市唐田乡2个村为试点,选择6～65岁村民随机配对分为青蒿琥酯组和对照组。在服青蒿琥酯前20天,先服单剂吡喹酮50mg/kg。于5月下旬口服第1剂青蒿琥酯6mg/kg,以后每半个月重复给药1次,共服10次,对照组口服相同剂型的安慰剂(淀粉),在停药后4周以粪检评价效果。结果显示,口服青蒿琥酯323人的粪检血吸虫卵阳性率为0.31％,无血吸虫急性感染发生,对照组323人的粪检血吸虫卵阳性率为9.60％,平均克粪便虫卵数(EPG)为4.00±3.50,出现急性血吸虫感染1例。用药前后对肝、肾功能、网织红细胞和心电图检查未见明显变化。结果表明在感染季节每半个月口服青蒿琥酯1次,对湖沼型重度血吸虫病流行区人群有较好的预防作用。更多还原

【Abstract】 To study the preventive effect of oral artesunate in an endemic area of schistosomiasis in marshland optimize the programme of administration of the medicine. From Apr. to Nov. in 1996, two villages of Tangtian township of Guichi city in Ahhui province were selected as the pilot of study, Villagers aged 6-65 selected were randomly grouped into the artesunate group and the control group. Before 20 days of administration of artesunate, all target villagers were detected by stool examination, and then treated with praziguantel at a single dose of 50mg/kg. In the artesunate group, the first dose of 6mg/kg was given in the last ten-day of May, and repeated dose every 15 days for 9 times and 10 times totally. Placebo (starch) which dosage form is as the same as that of artesunate was given to target villagers in the control group at the same time as in artesunate group. The effect was evaluated by stool examination after 4 WK of the last administration. The result showed that 1 case among 323 target villagers in the artesunate group revealed positive with positive rate of 0.31％ by stool examination. While in the control group, 30 cases among 323 target villagers showed positive with a positive rate of 9.60％, in which the mean egg pregram of feces (EPG) was 4.00±3.50 by Kato-Katz method. There was, statistically, significant difference between both groups. 1 case of acute infection of schistosomiasis was found in the control group, but none was found in the artesumate group. The blood and urine routine test, the hepatic and renal function tests and EKG was detected after the last administration, no abnormal changes were found. The result indicates that the preventive administration of artesumate of 6mg/kg repeated every 15 days during the transmission season exhibited a promising preventive effect for the villager in the serious endemic area of schistosomiasis in marshlands.更多还原