【摘要】 观察96例患者使用乙胺碘呋酮(AM)对QTc离散度(QTcd)的影响。非器质性心脏病组(n=22)及无明显心脏扩大、心功能不全、低钾表现的器质性心脏病组(n=41),治疗前后QTcd均无显著性差异(P>0.05);伴明显心脏扩大,心功能不全,部份患者有低钾表现的器性心脏病组(n=33),治疗前后QTcd差异有高度显著性(P<0.01)。3例发生恶性心律失常者,其QTcd均≥90ms。结果提示AM用于非器质性心脏病及无明显心脏扩大,心功能不全,低钾表现的器质性心脏病者,其QTcd无明显增加;用于有明显心脏扩大,心功能不全及低钾表现的器质性心脏病者。QTcd明显增加;使用AM发生恶性律失常者主要见于QTcd明显增大者。更多还原

【Abstract】 The effects of using Amiodarone (AM) in 96 patients on QTc dispersion (QTcd) were observed.The QTcd wasn’t obviously statistical different (p >0.05) before using AM and after using AM both in the group of nonparenchymal heart disease (n = 22) and in the group of parcnchymal heart disease (n = 41) without obvious enlargement of heart cardiac insufficiency and hypokalemia But the QTcd was highly statistical different (p<0.01) berore nsing AM and after using AM in the group of parenchymal heart disease (n = 33) with obvious enlargement of heart cardiac insufficiency and hypokalcmia existing in sot(?)of the patients. The QTcd of 3 patients to whom pernicious atthythmia happened was all≥90 ms The results have suggested that QTcd doesn’ t obviously increase after using AM in the patients of nonparenchymal heart disease and parenchymal heart disease without obvious enlargement of heart cardiac insufficiency and hypokalemia and that the QTcd obviously increases after using AM in the pationts of parenchymal hcart diseaes with obvious enlargement of heart cardiac insufficiency and hypokalmia. The reults have also suggested that the patients who have pernicious orrhythmia after taking AM are mainly the cases whose QTcd ohviously increases更多还原