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恶性黑色素瘤的病理及免疫组化诊断

THE PATHOLOGICAL AND IMMUNOHISTOCHEMICAL DIGNOSIS OF MELANOMAS

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【作者】 胡文浩李峰潘晓玲曹裕文王海明

【Author】 Hu Wenhao et al Department of pathology

【机构】 石河子医学院病理教研室石河子医学院文献检索教研室

【摘要】 对22例确诊或疑为恶黑瘤的病例进行了临床病理研究.其中13例确诊者和5例有争议的恶黑瘤做了免疫组化染色,结果显示:13例确诊者HMB-45染色均为阳性,而S-100染色12例阳性,NSE9例阳性.5例疑诊病例中,3例HMB-45S—100呈阳性而确诊为恶黑瘤.本研究再次表明HMB-45和S—100蛋白在恶黑瘤诊断中的实用价值.

【Abstract】 Twenty-two cases of confirmed and suspected melanoma were studied micro-copically. 18 cases of them were stained immunohistochemically with HMB-45、S-100、NSE and Keratin. The results showed that 13 cases of confirmed melanoma were positive to HMB-45. 12 cases were positive to S-100. 9 cases were positive to NSE,respectively. Among 5 suspicious cases ,3 were positive for HMB-45 and S-100 stains. This study confirmed that HMB-45 and S-100 protein are very useful in the diagnosis of melanomas.

  • 【分类号】R739.5
  • 【被引频次】4
  • 【下载频次】79
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