【摘要】 观察联合用药对实验性家兔海水型肺水肿的呼吸混沌动力学特性影响,用2 mg/kg海水通过肺支气管灌注复制海水肺水肿模型。用东莨菪碱(0.06 mg/kg)、氨茶碱(50 mg/kg)、纳络酮(0.08 mg/kg)耳缘静脉注射治疗肺水肿。0.9％NaCl静脉注射(4.2 ml/kg)作为药物对照组。用生理信号计算机采集系统对数据进行实时采集。正常家兔呼吸Lyapunov指数L1=0.060 10±0.099 43((?)±s),海水型肺水肿L1=3.76 41±2.94 89((?)±s)。呼吸时间序列数据二维、三维混沌空间散点图显示海水型肺水肿的混沌吸引子空间结构较正常发生改变,用药后L1值和混沌图部分接近正常,混沌动力学分析方法可以应用于肺水肿早期诊断及药物治疗效果的评价。更多还原

【Abstract】 The effects of combined drugs on respiration chaos dynamic properties of rabbit lung edema induced by seawater were observed experientially for the evaluation of Lya-punov exponents and chaos strange attractors in early diagnoses and drug treatment. The rabbit lung edema experimental model was made by putting seawater to lung through instillation (2 mg/kg). Scopolamine hydrobromidi(0. 06 mg/kg) ,aminophyllini(50 mg/kg)and naloxone (0. 08 mg/kg) were injected through veins in the ears. 0. 9% NaGl(4. 2 ml/kg) was also injected as the control group to the drug group. The data of respiration were collected by the computer system of physiological signals. Respiration LI of Lyapunov exponents in normal rabbits is 0. 60I 0 ±0. 994 3((?)±s) ,in lung edema induced by seawater ,LI = 3. 764 I±2. 948 9((?)±s). The figures of two and three dimensional chaos phase scattering graphs about the respiration time serial data show that there are changes in the space structures of chaos strange atractors in lung edema. After drug treatment , the LI values and the chaos graphs are close to normal states in part. The method of chaos dynamic analysis could be used in diagnoses ,evaluations and drug treatment for lung edema.更多还原