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麻风家内接触者的血清流行病学研究——两年随访

Second Follow-up of Household Contacts with Seropositivity to Leprosy Antigens

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【摘要】 用检测抗ND—O—BSA抗体的ELISA,对初次调查时抗体阳性的200名健康人和119例麻风家庭接触者进行的血清学随访(1993年)中分别26.5%和23.5%仍为阳性。初次检查抗体为阳性,而在第1次(1992年)随访时阴转者,以及初次检查及第1次随访均阴性的健康人和接触者,在本次随访中又变为阳性的分别为20.1%~33.0%和13.8%~36.0%。初次检测及两次随访均阳性的健康人和接触者,其抗体水平均最高。随访2年时,在抗体持续阳性者中共发现5例多菌型麻风。抗体持续阳性,麻风菌素晚期反应阴性的青少年发病的危险最大,家内接触者尤甚。

【Abstract】 Two hundred healthy controls and 119 leprosy household contacts who were of antibody positivity in 1991 have been followed up with serological method once a year for consecutive two years. Two hundred and twenty two healthy controls and 71 leprosy household contacts who were antibody negative in 1991 have also been followed up at the same time. The results showed that 26. 5% and 23. 5% of healthy controls and household contacts with antibody positivity in 1992 were still positive in 1993. The rates of converting to antibody positivity in healthy controls and the contacts with antibody negativity were 20. 1 to 33. 0% and 13. 8 to 36. 0% respectively. The mean antibody tilers of healthy controls and household contacts with persistent antibody positivity were the highest in 1993. Five MB leprosy patients were detected in the second follow-up. The study suggested that youngsters with persistent antibody positivity and lep-romin negativity have high risk of developing clinical leprosy, and the risk in household contacts was higher than that in the healthy controls. Trial skin smear in individuals with the high risk is very helpful to early detection of MB leprosy.

【关键词】 麻风亚临床感染流行病学早期发现
  • 【分类号】R755
  • 【被引频次】2
  • 【下载频次】13
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