【摘要】 本文检测了２５例正常人和２０例白血病患者的淋巴细胞转化率（ＬＴ）、Ｅ－玫瑰花环形成率（Ｅ-ＲＦ）、白介素－２水平（ＩＬ－２）、自然杀伤细胞（ＮＫ）活性和淋巴细胞因子激活的杀伤细胞活性（ＬＡＫ），以及经ＩＬ－２／ＬＡＫ疗法治疗前后白血病患者细胞免疫功能的变化。结果表明白血病患者ＬＡＫ活性和细胞免疫功能显著低于正常人（Ｐ＜０．０ｌ）；抗ＣＤ＿３单克隆抗体（ＣＤ＿３ＭｃＡｂ）可显著增强ＬＡＫ细胞活性；经ＩＬ－２／ＬＡＫ为主的生物治疗后患者ＬＴ和Ｅ－ＲＦ明显增高（Ｐ＜０．０５）。证明ＩＬ－２／ＬＡＫ为主的生物治疗方法能够不同程度地逆转白血病患者细胞免疫功能的缺陷。更多还原

【Abstract】 he cellular immune functions of 25 normal volunteers and 20 letikemia patients with IL-2/LAK thera-py were collected.The results showed that LAK and NK cells activities、secretion of interleukin-2 from lym-phocytes（IL-2）、rates of lymphocyte transformation and E-rose formation（E-RF）in leukemia cases were much lower than those in volunteers （P<0.0l）;Anti-CD₃ monoclonal antibody（CD3McAb）could markedly enhance LAK cell activity in volunteers and leukemia cases. After treatment with IL-2/LAK therapy,lym-phocyte transformation and E-RF in leukemia patients were higher than that before treatment（ P<0.05 ）.These indicates that IL-2/LAK biotherapy is able to reverse the decrease of cellular immune functions in leukemia cases.更多还原