【摘要】 实验用30只青紫兰家兔,随机分A组(注射阿霉素),B组(注射阿霉素和丹参)和C组(对照组),实验8周后处死动物,留取心肌标本作光镜及电镜观察。结果发现:心肌组织损伤主要位于乳头肌、肉柱及心内外膜下区域并集中于微血管周围;超微结构改变包括心肌细胞本身病变和间质毛细血管病变。同时发现B组光、电镜病变均比A组轻;B组家兔生存时间比A组明显延长。结果提示丹参对家兔阿霉素性心肌病有保护作用。更多还原

【Abstract】 30 Chinbhilla rabbits were used and randomly divided into three groups;Group A(10 rabbits) received adriamycin(ADR) only; Group B(10 rabbits)were given ADR and Radix Salviae Miltiorrhize (RSM); and Group C(10 rabbits) received normal Saline. The experiment lasted 8 weeks. Rabbits were sacrificed at the end of the experiment, those in agonal condition were also killed. The myocardial morphologic alterations were examined by light and electron microscopy. The results showed the myocardial lesions were mainly located in the papillary muscles, trabeculae carneae, subendocardial and subpericardial rigions and were frequently concentrated Perivascularlly; Ultrastructurally, the alterations of myocytes and intramyocardial capillaries were very conspicuous. The morphologic analysis showed the cardiac lesions were significantly milder in rabbits supplemented with RSM than those received ADR only(P<0. 01-0. 05);the survial time was prolonged in Group B. The results suggested that cardiomyopathy of ADR may be protected partially by RSM.更多还原