【摘要】 本文研究８名健康志愿者口服单剂量普萘洛尔（４０ｍｇ）和１２名健康志愿者口服多剂量普萘洛尔（８０ｍｇ／ｄａｙ×３）后；静息状态和踏车兴奋状态时血浆心钠素（ＡＮＰ）水平的变化。口服单剂量普萘洛尔后３ｈ，静息状态时血浆ＡＮＰ水平升高１９．４±１１．１ｎｇ／Ｌ（Ｐ＜０．０５）；而运动状态时血浆ＡＮＰ升高更为明显，为６４．８±４０．９ｎｇ／Ｌ（Ｐ＜０．０５）。血浆ＡＮＰ的变化与普萘洛尔对映体Ｓ（－）－ＰＰＬ和Ｒ（＋）－ＰＰＬ浓度均具有良好的线性相关性，相关系数分别为０．８５６３和０．７１９２。口服多剂量普萘洛尔停药后１２ｈ，血浆ＡＮＰ仍可维持较高水平，较基础对照值升高３９．９±２８．３ｎｇ／Ｌ（Ｐ＜０．０５）。此结果提示，普萘洛尔参与了血浆ＡＮＰ水平的调控，这种作用尚难以用β肾上腺素能效应进行解释，可能与抑制ＡＮＰ的体内降解过程有关。更多还原

【Abstract】 The aim of this study is attempt to elucidate whether the beta-adrenoceptor is involved in the regulation of the plasma levels of atrial natriuretic peptide (ANP) in & healthy volunteers who received a single dose of recemic propranolol (40mg) at rest and in 12 healthy volunteers who received multiple doses of racemic propranolol(80mg/day for 3 days ) during graded maximal ergocycle exercise.Plasma ANP concentrations were measured by radioimmunoassay.At 3h after oral single dose of racemic propranolol,the resting plasma ANP level was increased by 19. 4±11. lug/L compared with the hasal value (P＜0. 05 ),and the exercising plasma ANP level was more significantly increased by 64. 8±40. 9ng/L (P＜0. 05 ). There　was significant correlation between the plasma ANP levels and the plasma ding concentlations of enantiomer S　(-)-propranolol or R(+)-propranolol, the correlation coefficients were 0.9563 and 0.7192 respectively.At 12h after last dose in oral multiple doses of racemic propranolol, the rise was still maintained at a high levi, plasma ANP was increased by 39. 9±28. 3ng/L compared with the hial value (P＜0. 05 ). These results suggest that propranolol is involved in the control of plasma ANP level, and beta-adrenoceptor mechanisms are not directly responsible for the regulation.更多还原