【摘要】 采用抗ＰＣＮＡ单克隆抗体ＰＣ１０，对９６例乳腺良恶性病变组织进行免疫组化表达研究。其中乳腺增生性病变３１例，乳腺非典型增生１５例，乳腺癌Ⅰ级１２例，Ⅱ及２３例，Ⅲ级１５例。结果显示：ＰＣＮＡ染色强度指数良性病变为３９．８０，非典型增生４０．７１，Ⅰ级乳腺癌５４．５８，Ⅱ级６６．８３，Ⅲ级１０８．７４．各级乳腺病变之间可见差异有高度显著性（Ｐ＜０．０１）。表明ＰＣＮＡ指数与乳腺病变及乳腺癌组织的分级有密切关系。更多还原

【Abstract】 The expression of proliferating cell nuclear antigen(PCNA)was studied by using a monoclonal antibody PC10 with immunohistochemistry in 96 cases of breast benign diseases and breast cancer tissues.The results showed that PCNA staining intensity index(SII)was 39.80 in breast proliferating diseases,40.71 in breast atypia proliferation,54.58 in breast carcinoma grade Ⅰ,66.83 in grade Ⅱ,and 108.74 in grade Ⅲ.The difference was statistically significant(P<0.01),indicating close relationship between PCNA index and histological grading of breast tumor.更多还原