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偏头痛患者血浆中β-内啡肽含量观察

Plasma beta-endorphin level in migraine without aura

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【作者】 张志坚许国英方玲慕容慎行吴秀丽

【Author】 Zhang Zhijian Xu Guoying Fang Lin Department of Neurology,The First Affiliated Hospital of Fujian Medical College,Fuzhou 350005.

【机构】 福建医学院附属第一医院神经内科福建医学院附属第一医院神经内科

【摘要】 为探讨β-内啡肽与偏头痛发病的关系,我们用放射免疫法测定了44例无预兆偏头痛患者与25例正常对照者的血浆β-内啡肽水平,结果发现β-内啡肽水平在偏头痛组较正常对照组降低;男性患者组较女性患者组低。提示偏头痛患者很可能存在内源性阿片肽系统某个环节的缺陷。

【Abstract】 In order to explore the relationship between beta-endorphin and migraine at- tack,the plasma beta-endorphin level in 44 cases of migraine without aura and 25 cases of normal controls were determined with radioimmunoassay.The results showed the plasma be- ta-endorphin level in migraine without aura was lower(239.0±156.4pg/L)than that in normal controls(407.5+257.4pg/L),and in male patients was lower(147.2+79.5pg/ L)than that in female(269.7+164.4pg/L).The possible defect of endogenous opioid sys- tem in migraineurs was suggested.

【关键词】 偏头痛β-内啡肽
【Key words】 MigraineBeta-endorphin
  • 【文献出处】 临床神经病学杂志 ,Journal of Clinical Neurology , 编辑部邮箱 ,1996年02期
  • 【分类号】R747.2
  • 【下载频次】39
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