【摘要】 对90例吸烟与非吸烟精神分裂症患者进行氯氮平剂量、血浓度、疗效等作相关性研究。结果发现,吸烟患者氯氮平剂量显著高于非吸烟者,而血浓度前者显著低于后者,疗效后者显著优于前者。作者认为,精神分裂症患者在接受氯氮平治疗期间应禁止吸烟,这有利于提高氯氮平的疗效、减低剂量,对出院后的坚持服药、降低复发率等均有积极意义。更多还原

【Abstract】 Objective: To detect differences in serum drug level and theraupeutic effect of clozapine in smoking vs. non—smoking schizophrenic patients. Method: 90 smoking and non—smoking schizophrenic patients were evaluated with respect to the dosage of clozapine, serum drug level and therapeutic effect. Result: The dosage of clozapine was significantly higher in smoking patients than in non—smoking patients, while the serum level was significantly lower in smoking patients. The therapeutic was also significantly better in non—smoking patients. Discussion: We suggested that during treatment with clozapine in schizophrenic patients, smoking should be forbidden as far as possible. This procedure can enhance the effect of clozapine and decrease its dosage. This has positive implications on maintenance therapy with clozapine after schizophrenic patients are discharged from hospitals.更多还原