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Preliminary X-ray diffraction study on haemorrhagin AaHⅢ from snake venom of Agkistrodon acutus

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【Author】 GONG Weimin ZHU Zhongliang NIU LiwenTENG Maikun(Young Scientist Laboratory of Structure Biology, University of Science and Technology of China, Hefei 230026, China)Department of Biology,University of Science and Technology of China,Hefei 230026,ChinaState Key Laboratory of Biomacromolecules,Chinese Academy of Sciences,Beijing 100080,China

【机构】 Department of Biology； University of Science and Technology of China； Hefei 230026； China； Young Scientist Laboratory of Structure Biology； University of Science and Technology of China； Hefei 230026； China； State Key Laboratory of Biomacromolecules； Chinese Academy of Sciences； Beijing 100080； China；

【摘要】 <正> Haemorrhagins,Which cause local haemorrhage or even death after injection into exper-imental animals,exist widely in many kinds of snake venoms.Almost allthe haemorrhagins reported are zinc-metalloproteinases with highly conserved amino acid se-quences.Some of them could degrade the proteins in matrices so that they are the im-portant targets for drugs to combat diseases such as arthritis and cancer.Snake venommetalloproteinases can be divided into three classes based on their molecular weights:low更多还原

【关键词】 crystal； haemorrhagin； metalloprotcina.se； snake venom.；
【Key words】 crystal； haemorrhagin； metalloprotcina.se； snake venom.；

【基金】 Project supported by the State Key Laboratory of Biomacromolecules, Chinese Academy of Science and State Foundation Commission of China.

【文献出处】 Chinese Science Bulletin ,科学通报(英文版) , 编辑部邮箱 ,1996年21期

【分类号】Q592
【下载频次】20

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