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Interaction of metal ions, Mn2+ and Ni2+, with calcineurin

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【作者】 周捷向本琼魏群卢景芬

【Author】 ZHOU Jie XIANG Benqiong WEI Qunand LU Jingfen(Laboratory of Molecular Biology and Biochemistry, Beijing Normal University, Beijing 100875, China)

【机构】 Laboratory of Molecular Biology and BiochemistryBeijing Normal UniversityBeijing 100875ChinaChina

【摘要】 <正> Calcineurin(CaN,EC 3.1.3.16)is the only known calcium/calmodulin-dependentphosphoprotein phosphatase.The molecular weight of holoenzyme is 80ku;the largesubunit A(61 ku)is the catalytic subunit;the small subunit B(19ku)is the regulatorysubunit and similar to calmodulin.The phosphatase activity of CaN is divalent-cations-dependent,Mn2+ and Ni2+ can activate the enzyme to the highest level.Since Mn2+

【基金】 Project supported by the National Natural Science Foundation of China;National Laboratory of Biomacromolecules.
  • 【文献出处】 Chinese Science Bulletin ,科学通报(英文版) , 编辑部邮箱 ,1996年12期
  • 【分类号】Q55
  • 【下载频次】26
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