【摘要】 目的 探索发作性睡病的多导睡眠脑电图特点以及与HLA的关系。方法 回顾从1986年至1994年在睡眠实验室检查的508名对象,按以下标准筛选出发作性睡病:睡眠潜伏期缩短至5分钟以内;在5个20分钟瞌睡周期中有2个或2个以上出现快眼动睡眠(REM)。结果 共检出9例发作性睡病,在实验检查人群中的患病率是1.8％。所有病例均为HLA的DR2阳性型,也是HLA的DQ_w1阳性。结论本研究筛选病例的临床表现与其他人种的报道相似。他们都是HLA的DR2及DQ_w1型。更多还原

【Abstract】 Objective: To explore the clinical and polysomnographic characteristics of Chinese narcoleptic patients and their HLA typing. Methods: The records of 508 patients who presented to our sleep laboratory for various sleep problems from 1986 to 1994 were examined. Both clinical and polysomnographic data were analyzed. The criteria for a diagnosis of narcolepsy is based on shortened mean sleep latency of less than 5 minutes and presence of rapid eye movement sleep in 2 or more of the five 20-minute naps during multiple sleep latency test. Results: There were 9 narcoleptic patients documented resulting in an overall laboratory prevalence of 1.8% or 2.45% of patients presenting with hypersomnia. All narcoleptic patients were HLA DR2 positive. As far as we could ascertain, they were also HLA DQw1 positive. Conclusion: The overall symptom pattern of narcolepsy in this sample was quite similar to that reported in other ethnic groups. There is 100% association with HLA DR2 and DQwl in Hong Kong Chinese narcoleptic patients.更多还原