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“更年健”对老年雌性大鼠中缝背核5-羟色胺的影响

EFFECT OF "GENG NIAN JIAN" ON SEROTONIN IN DORSAL RAPHE NUCLEUS OF AGING FEMALE RATS

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【作者】 步世忠孙梅俞瑾张沅

【Author】 Bu Shizhong , Sun Mei, Zhang Yuan, Yu JinObstetrics & Gynecology Hospital, Shanghai Medical niversity , Shanghai 200011 State Key Laboratory of Motecular Biology, Shanghai Institute ofB lock em istry , A cad emia Sinica

【机构】 上海医科大学妇产科医院中国科学院上海生化所分子生物学国家重点实验室 上海200011上海200011

【摘要】 应用免疫组织化学和计算机图像分析技术,观察中药“更年健”对老龄雌性大鼠中缝背核5-HT的影响.结果表明:“更年健”和苯甲酸雌二醇用药后,中缝背核5-羟色胺含量明显增高,与用药前相比.相差显著(P<0.01).提示“更年健”能增强老年雌性大鼠中缝背核5-HT神经元活性.

【Abstract】 The present work was designed to observe the effect of "Geng Nian Jian" on serotonin in dorsal raphe nucleus of aging female rats with immunohistochemistry and image processing. The results showed that 5-HT neurons increased significantly(P<0. 01), both in the "Geng Nian Jian" group and in the estradiol benoate group, which suggests that Gninese tranditionsl medicine "Geng Nian Jian" can increase the activity of 5-HT neurons in dorsal raphe nucleus of aging fe-male rats.

【关键词】 中脑中缝背核老年大鼠
【Key words】 dorsal raph nucleusagingrats
  • 【文献出处】 解剖学杂志 ,Chinese Journal of Anatomy , 编辑部邮箱 ,1996年04期
  • 【分类号】R285.5
  • 【被引频次】12
  • 【下载频次】68
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