【摘要】 用酶组织化学方法观察了自发性高血压大鼠（ＳＨＲ）和正常血压的ＳＤ大鼠在脑梗塞后缺血区的皮质微血管壁，以探讨大脑中动脉（ｍｉｄｄｌｅｃｅｒｅｂｒａｌａｒｔｅｒｙ，ＭＣＡ）阻断后梗塞区脑血管壁的代谢情况，结果显示，缺血１５ｍｉｎ，脑梗塞区血管壁的细胞色素Ｃ氧化酶（ＣＣＯ）和球肌蛋白ＡＴＰ酶（ｍｙｏｓｉｎＡＴＰａｓｅ）活性降低，乳酸脱氢酶（ＬＤＨ）的活性增强。随缺血时间延长，与ＳＤ大鼠相比较，ＳＨＲ脑血管壁的上述变化更为明显，提示ＳＨＲ脑血管壁对缺血具有高度的敏感性。更多还原

【Abstract】 Enzyme-histochemistry was used to explore metabolic profiles of cerebrovascular walls of rats With ischemia by the occlusion of the middle cerebral artery(MCA)in 50 spontaneously hypertensive rats(SHR)and 50 Sprague-Dawley(SD)rats. The results showed that the activities of cytochrome C oxidase (CCO)and myosin-ATPase in cerebral microvascular walls of SHR were lower than those of SD rats,and the activity of lactate dehydrogenase(LDH)in the vascular walls of SHR was higher than that of SD rats. These alterations occurred at 15 min after the occlusion of the MCA and the changes were progressive with the prolonged ischemic time.These results suggested that the cerebral vessels of SHR were more susceptive to ischemia compared with those of SD rats.更多还原