【摘要】 在三聚氯氰存在下，（２－环己酮基）－β－丙酸与（Ｒ）－四氢噻唑－２－硫酮－４－羧酸酯（甲酯、乙酯、正丁酯、正戊酯）反应，得到相应的Ｎ－（２－环己酮基）－β－丙酰－（Ｒ）－四氢噻唑－２－硫酮－４－羧酸酯１（ａ～ｄ），［α］＿Ｄ￣（２０）分别为－５０．３°，－５０．９°，－５０．０°，－７８．１°．１（ａ～ｃ）与Ｒ，Ｓ－α－苯乙胺反应得到了光学活性的Ｎ－（２－环己酮基）－β－丙酰－α－苯乙胺及Ｒ过量的α－苯乙胺．更多还原

【Abstract】 2-Cyclohhexanonyl)-β-propionyl-(R)-thiazolidine-2-thione-4-carboxylic esters(1a-d)(methylester,ethyl ester,n-butyl ester n-pentyl ester)were obtained from the dehydration of(2-cyclohexanonyl)-β-proplonlc acid with (R)-thiazolidine-2-thione-4-carboxylic esters in the presence of cyanuryl chloride as the coupling reagent.Compounds 1a c react With R,S-a-phenylethylamine to form optically activeN-(2-cyclohexanonyl)-β-propionyl-a-phenylethylamine and(R) leave the a-phenylethylamine excess.更多还原