【摘要】 观察排卵期服用300mg米非司酮进行房事后避孕的效果和对月经的影响,在对照周期、用药周期和恢复周期,血浆雌二醇（E₂）、孕酮（P）和黄体生成素（LH）浓度的变化,以及米非司酮对分泌期子宫内膜的影响。接受85名育龄妇女为受试者。60例主要观察避孕效果和月经恢复情况,另25例在三个不同周期中,定期取静脉血测三种激素水平,并在服米非司酮后第4～5天,取子宫内膜进行形态学检查。共观察129个服药周期,妊娠率为0.78％。其中18个周期出现服米非司酮后阴道少量出血,但未干扰正常月经规律,无明显副反应发生。在用药周期和恢复周期中,血浆E₂、P和LH的水平未受影响。形态学检查显示子宫内膜发育延迟。本研究联合使用几种监测排卵方法,提示在排卵后72小时内服300mg米非司酮安全、有效,在分泌早期服用米非司酮可以考虑作为一月一次的避孕方法。更多还原

【Abstract】 considered for the use as a once a month pill for ferititv (?).Eight-five women wen- treated with the different doses of anti--progesteron Mifepristone 300mg, 150mg, 75mg. within 72 hours after unprotected intercourse during the ovulatory Period. A total of 129 treatment cycles were studied. Serum hormones and endometrial morphology were examined in partial subjects. The pregnancy rate was 0. 78% .as only one treatment cycle failed for the monitoring of ovularion mistaken and mifepristone not administered on the due time. The side effect was mild, the menstrual blood loss diminished slightly in 72%, Serum levels of oestradiol, progesterone and LH were not affected by the medicine. The endometrial morphological analysis revealed a retardation of development after the treatment. The results suggested that 300mg of mifepristone administered are effective and safe during ovulatory period. Thus .administration of mifepristone within 72 hours after unprotected intercourse during ovulatory period might be更多还原