【摘要】 采用ＭＴＴ法评价了人舌鳞状细胞癌ＳＣＣ－２５细胞对几种常用抗癌药物联合加温的敏感性，正常温度（３７℃）时ＳＣＣ－２５细胞对化疗药物敏感性顺序为：阿霉素、顺铂、丝列霉素Ｃ、博莱霉素、氨甲喋呤、匹莱霉素、５－氟脲嘧啶；４０～４５℃温度范围内，不同抗癌药物联合加温对ＳＣＣ－２５细胞杀伤作用表现出各自的最佳作用温度，在有效药物浓度条件下，药物浓度增加不能显著地改变药物联合加温的综合癌细胞杀伤效应。更多还原

【Abstract】 This paper reported on the anticancer effect of hyperthermochemotherapy for the human tongue cancer cell (SCC 25 cell line) in vitro. The result showed that (1) at 37℃ the order of drug sensitization was as follows: ADR, CDDP, MMC, BLM, MTX, PEP, 5 Fu; (2)under the 40￣45℃/40 min, the anticancer drugs showed an optimum effective temperature separately. The authors also observed the effects of drugs dosage for the hyperthermochemotherapy in this study.更多还原