【摘要】 对１１２例孕３７～４２周单胎头位、无严重合并疾患、宫颈Ｂｉｓｈｏｐ评分≤４分且无产兆的初产妇，随机分为２组，每组５６例，对照组不采用任何促宫颈成熟的药物，观察组每ｄ应用蒂洛安２００ｍｇ加５０ｇ／Ｌ葡萄糖液２０ｍｌ静脉推注，连用２～３ｄ，观察蒂洛安促宫颈成熟的作用。结果：观察组宫颈评分显著升高率７１．４３％，总有效率１００％。对照组宫颈评分显著升高率１４．２９％，总有效率３５．７１％。两组对比有显著差异（Ｐ＜０．００５），观察组１ｄ自然发动宫缩率及第２ｄ１次引产成功率为６４．２９％，显著高于对照组（７．１４％）（Ｐ＜０．０１）。两组在产后出血及新生儿Ａｐｇａｒ评分等方面差异无显著性（Ｐ＞０．０５）。提示：蒂洛安有明显的促宫颈成熟作用，可缩短分娩发动时间及提高１次引产成功率，对母儿无不良影响，为一安全、有效的促宫颈成熟药物。更多还原

【Abstract】 To observe the effect of sodium prasterone sulfate, DHA-S, on ripening uterine cervix, a prospective trial, divided into two groups at random, was carried out on 112 cases of primiparity with 37 to 42 gestation weeks, single fetus,cephalic presentation, no serious complications,initial Bishop<4 and no premonitory labor.DHA-S 200 mg was dissolved in 20 ml of 0.5% glucose solution and was injected intravenously once a day for two or three days. The resuIts showed that there were higher rates of Bishop Score(71.43%)in treated groups than those of the control group(14.2%).The total effective rate was 100% in the treated group,while that in the control group was 35.7%.There was a significantly higher difference between the two groups(P<0.005).There was a rate of uterine contractions happening spontaneously in a day after administration, and the successful rate of the following day’s induced labour(64.29%)in the treated group were higher than that in the control group. There were no significant differences in postpartum hemorrhage, neonate Apgar score et al(P<0.05).It suggested that DHA-S could significantly ripen the utering cervix,shorten the duration of the onset of labour,and increase the rate of first induced labour successfully.There were no adverse effects on mothers and infants. DHA-S is a safe and effective drug to ripen uterine cervix.更多还原