【摘要】 测定了４０例健康人群和３３例皮肌炎患者２４ｈ尿肌酸肌酐水平，并按Ｒｏｓｅ肌无力程度分级法将患者分为肌力Ⅱ级、Ⅲ～Ⅳ和Ⅴ～Ⅵ级３组。结果显示，皮肌炎患者各组２４ｈ尿肌酸明显高于健康对照组（Ｐ＜０．００１），但患者组间２４ｈ尿肌酸水平无显著性差异（Ｐ＞０．０５），２４ｈ尿肌酸与肌无力程度间亦无明显相关关系（Ｐ＞０．０５）。结果提示２４ｈ尿肌酸水平作为皮肌炎诊断依据之一尚且可靠，但用以观察病情变化尚欠准确。更多还原

【Abstract】 hours urinary creatine and creatinine were determined in 40 healthy volunteers and 33 patients with dermatomyositis(DM).The patients were divided into 3 groups according to Rose ergometry. They were myodynamia Ⅱ grade,Ⅲ～Ⅳ grade and Ⅴ～Ⅳ grade. The results showed that the levels of 24 hours urinary creatine in each group of patients were significantly higher than those in healthy volunteers(P<0.001).However, the levels of 24 hours urinary creatine had no correlation among the patient groups (P>0.05).Moreover,there was no correlation between 24 hours urinary creatine and amyosthenia (P>0.05).These results suggested that taking the levels of 24 hours urinary creatine as one of the diagnostic evidence of DM might be reliable,but it was certainly lack of accuracy to observe patients’condition alteration.更多还原