【摘要】 应用９９ｍＴｃ－ＭＩＢＩ直肠灌注进行门脉显像，根据心肌及肝区放射性计数测定核素心、肝比值Ｈ／Ｌ和门体分流指数ＳＩ作为门静脉循环参数与术中门静脉测压等指标作统计学处理。１２例正常对照组的ＨＩＬ为０．１４５±０．０４２，ＳＩ为０．１２４±０．０２９；１８例非肝硬化性肝胆疾病组的Ｈ／Ｌ为０．２０７±０．０７６，ＳＩ为０．１６９±０．０５（ｐ均＜０．０１）；４７例肝硬化组的Ｈ／Ｌ为０．７５１±０．３１３。ＳＩ为０．４２２±０．０７５（与对照组及非肝硬化性肝胆疾病组比较Ｐ均＜０．００１）；根据Ｃｈｉｌｄ－ｐｌｌｇｈ分级的Ａ、Ｂ、Ｃ三组间的差异亦有显著意义（Ｐ均＜０．０５）。Ｈ／Ｌ、ＳＩ与术中测压呈高度正相关（ｒ＝０．９５，Ｐ＜０．０１）。以Ｈ／Ｌ≥０．３０、ＳＩ≥０．２２为阳性，诊断肝硬化门脉高压的灵敏度为９６％、特异性为９０％、准确性为９４％。表明本方法可作为诊断肝硬化门脉高压的新方法。更多还原

【Abstract】 The portal hypertension of hepatic cirrhosis was studied by 99mTc-MIBI trans-rectum imaging. The portal systemic circulation was evaluated by the heart-liver ratio (H/L ratio) and the portosystemic shunt index (SI). The H/L and SI in 12 normal cases were 0.145 ± 0.042 and 0.124 ± 0.029. Whereas in 18 patients with hepatobiliary diseases of non-cirrhosis were 0.207 ± 0.076 and 0.169 ± 0.051, and in 47patients with hepatic cirrhosis were 0.751± 0.313 and 0.422± 0.075. The results showed significant difference (P<0.01) between normal controls and non-cirrhosis group, and significant difference (P<0.001) between hepatic cirrhosis group andnormal controls, non-cirrhosis group. A significant difference (P<0.05) in child-pugh’s classification A, B and C group was also found. A significant correlation (r=0.95, P<0.01) with the H/L, SI and portal pressure measurementduring operation was found. If H/L>0.30, and SI≥0.22 were taken as positive criteria for diagnosis of portal hypertension with hepetic cirrhosis, the sensitivity,specificity and accuracy were 96%, 90% and 94% respectively.Therefore, it was a new method for the diagnosis of portal hypertension with hepatic cirrhosis.更多还原