【摘要】 研究了１９１例人体透明质酸（ＨＡ），发现胚胎组织中ＨＡ含量为（２０３８．３９±３３６．５１μｇ／Ｌ），新生儿血清ＨＡ值为７２０．８１±３８５．７６１１９／Ｌ，随着年龄增大血清ＨＡ逐渐下降，大约６月龄后血清ＨＡ较稳定地保持在４５．９２±３５．９２μｇ／Ｌ水平；肿瘤患者血清ＨＡ增高，中枢神经系统肿瘤脑脊液中ＨＡ显著增高。由于ＨＡ在新生儿中存在着胚胎现象，所以成年肿瘤患者血液或脑脊液中ＨＡ增高可能与“癌胚现象”有关。更多还原

【Abstract】 Human hyaluronic acid(HA) in 191 healthy donors were studied.It was found that serum HA concentration was significantly elevated(2038.39±336.51 μg/L)in fetuses and still at higher level(720.81±385.76μg/L)in neonates. It decreased gradually with aging and maintained a steady state at 45.92±35.92 μg/L 6 months after birth. Patients with neoplasm had increased HA in blood,and an elevated HA value in CSF was noted for patients with malignancy of central nervous system.As fetal tissues contain a large amount of HA,increased HA concentration in patients with neoplastic disease may be regarded as an oncofetal phenomenon.更多还原