【摘要】 应用免疫组织化学技术对４８例大肠癌标本进行了雌激素受体（ＥＲ）检测。结果发现ＥＲ的阳性率为３７．５％。４８例大肠癌按组织学分型，ＥＲ阳性率分别为：高分化腺癌组５２．３％；中分化腺癌组３８．９％；低分化腺癌组１１．１％。高分化腺癌与低分化腺癌组比较，ＥＲ阳性率有显著差别（ｐ＜０．０１）。４８例大肠癌标本按部位、性别、年龄分组，１９例结肠癌中，ＥＲ阳性率４２．１％，２９例直肠癌中，ＥＲ阳性率３４．５％（ｐ＞０．０５）。３８例男性中，ＥＲ阳性率为３４．２％，１０例女性中，ＥＲ阳性率４０．０％（ｐ＞０．０５）。８例＜４５岁中，ＥＲ阳性率２５．０％，４０例＞４５中，ＥＲ阳性率４０．０％（ｐ＞０．０５）。结果提示，部分大肠癌归属于雌激素依赖性肿瘤。ＥＲ水平与大肠癌分化程度有关，与部位、年龄、性别无关。更多还原

【Abstract】 With the use of immunohistochemical techniques, the expressin of estrogen receptor (ER)in 48 specimen of large intestinal carcinoma were examined. The results showed that the ER positive rate was 37.5%, By divided of pathology in 72 specimen,ER positive rate was 52. 3%in well-differentiated adenocarcinoma, 38.9%in moderately-differentiated adenocarcinoma,11.1% in poorly-differentiated adenocarcinoma.there were significant difference between the well differentiated adenoocarcinoma and poorly-differentiated adenocarcinoma(p<0. 01 ). By divided of site or sex or age in48 specimen, ER positive rate was 42. 1%in colon carcinoma, 34. 5%in rectum carcinoma (p>0. 05%); ER positive rate was 34. 2%in male, 40.0% in fimal(p>0. 05);ER positive rate was 25.0% in thhose<45 years of ages, 40.0% in those>45 years of ages(p>0.05). The resolts soggested that some of large intestinal carcinoma belong to the tumors of estron dependence. The expression of ER has association with the degree of histological differentiation, but has no assoociation with the site, sex and age.更多还原